By Neera Vohra on December 12, 2012
“For the first time ever, University of B.C. scientists have used human embryonic stem cell transplants to reverse Type 1 diabetes in mice with the disease, giving hope to about 300 million people around the world who suffer from the chronic disease.
The study by a 13-member team, lead by LSI Researcher, Tim Kieffer, is published in the journal Diabetes, shows that after transplantation, the stem cells matured into insulin-secreting, pancreatic beta-cells. The cells automatically sensed blood sugar levels to release the right amount of insulin and a few dozen diabetic mice were gradually weaned off insulin given to them over a period of months.” Vancouver Sun, June 27, 2012
The new study received extensive media coverage including in the Vancouver Sun and Global TV
Image on the left shows stem cell derived insulin containing cells (red) and glucagon expressing cells (green) with a nuclear stain (blue) after transplant and maturation, appearing very similar to insulin and glucagon producing cells found in human pancreas (right image).
Posted in Featured, Slideshow
By smuni on December 6, 2012
Adam W. Plumb, Daniel T. Patton, Emma-Kate Loveday, François Jean, Steven F. Ziegler & Ninan Abraham (2012). Interleukin-7, but Not Thymic Stromal Lymphopoietin, Plays a Key Role in the T Cell Response to Influenza A Virus. Publication appearing in PLOS ONE, November 2012. DOI:10.1371/journal.pone.0050199
Posted in Publications
By smuni on December 5, 2012
Vince C. Chen, Joost W. Gouw, Christian C. Naus & Leonard J. Foster (2012). Connexin multi-sites phosphorylation: Mass spectrometry-based proteomics fills the gap. Publication appearing in Biochim Biophys Acta – BiomembranesJanuary 2013. DOI:10.1016/j.bbamem.2012.02.028
Posted in Publications, Uncategorized
By smuni on December 4, 2012
Linda Matsuuchi and Christian Naus, 2012. Gap junction proteins on the move: Connexins, the cytoskeleton and migration, Biochim Biophys Acta – Biomembranes, October 2012. DOI: 10.1016/j.bbamem.2012.05.014
Posted in Publications
By smuni on December 4, 2012
Arya E. Mehran, Nicole M. Templeman, G. Stefano Brigidi, Gareth E. Lim, Kwan-Yi Chu, Xiaoke Hu, Jose Diego Botezelli, Ali Asadi, Bradford G. Hoffman, Timothy J. Kieffer, Shernaz X. Bamji, Susanne M. Clee, & James D. Johnson (2012). Hyperinsulinemia drives diet-induced obesity independently of brain insulin production, December 2012. DOI:org/10.1016/j.bbr.2011.03.031
To read the full article in The Vancouver Sun
Posted in Publications
By smuni on November 15, 2012
The C. elegansDeletion Mutant Consortium (2012). Large-Scale Screening for Targeted Knockouts in the Caenorhabditis elegans Genome. The Journal of G3•Genes Genomics Genetics, November 2012. DOI:10.1534/g3.112.003830
Posted in Featured, Publications, Slideshow
By smuni on November 13, 2012
Georgia Perona-Wright, Jacob E. Kohlmeier, Elizabeth Bassity, Tori Freitas, Katja Mohrs, Tres Cookenham, Haozhong Situ, Edward J. Pearce, David L. Woodland & Markus Mohrs (2012). Persistent loss of IL-27 responsiveness in CD8+ memory T cells abrogates IL -10 expression in a recall response. The Journal of Proc. Natl. Acad. Sci (PNAS), October 2012. DOI:10.1073/pnas.1119133109
Posted in Featured, Publications
By smuni on October 29, 2012
Jeffrey W. Stafford, Kaylea M. Lynd, Aera Y. Jung and Michael D. Gordon (2012).Integration of Taste and Calorie Sensing in Drosophila. The Journal of Neuroscience, October 2012. DOI:10.1523/JNEUROSCI.1887-12.2012
Posted in Publications, Uncategorized
By smuni on October 7, 2012
Posted in Uncategorized
By smuni on October 6, 2012
Mary Pines, Raibatak Das, Stephanie J. Ellis, Alexander Morin, Stefan Czerniecki, Lin Yuan, Markus Klose, Daniel Coombs and Guy Tanentzapf (2012). Mechanical force regulates integrin turnover in Drosophila in vivo, Nature Cell Biology, September 2012. DOI:10.1038/ncb2555
Posted in Featured, Publications
