Whole-Genome Profiling of Mutagenesis in Caenorhabditis elegans

Authors: Stephane Flibotte, Mark L. Edgley, Iasha Chaudhry, Jon Taylor, Sarah E. Neil, Aleksandra Rogula, Rick Zapf, Martin Hirst, Yaron Butterfield, Steven J. Jones, Marco A. Marra, Robert J. Barstead and Donald G. Moerman.  Lab of Donald Moerman, Cell & Developmental Biology Research Group, Department of Zoology.

Published in Genetics; Volume:  185; June 2010; Pages:  431-441 doi:10.1534/genetics.110.116616

Abstract: Massively parallel short read sequencing technologies portend a revolution in genetic analysis and discovery. In Sarin et al. (Genetics vol 185 pp. 417–430) and Flibotte et al. (Genetics vol 185 pp. 431–441), this technology is used to describe, in exquisite and unprecedented detail, changes throughout the genome after mutagenesis in the nematode Caenorhaditis elegans. Image designed by Aleksandra Rogula, one of the authors.